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Environmental applications of luminescence

Simultaneous determination of naproxen and ibuprofen by synchronous fluorescence spectroscopy (SFS) in cyclodextrin and micellar media

Jean M. D. Bakhoum1, Olivier M. A. Mbaye2, Jean P. Bakhoum2, Mame D. Gaye-seye2, Clément Trellu3, Atanasse Coly2, Jean-jacques Aaron3

1Laboratoire de Photochimie et d\'Analyse, Cheikh Anta Diop University, Department of chemistry, Senegal, 2Laboratoire de Photochimie et d'Analyse, Cheikh Anta Diop University, Department of chemistry, Senegal, 3Laboratoire Géomatériaux et Environnement (EA 4508), Gustave Eiffel University, France

E-mail: olivier.mbaye@ucad.edu.sn

Despite their positive effects, drugs represent a major source of pollution for the aquatic and terrestrial environment. Concentrations in the environment generally range from ng/L to μg/L. The worldwide presence of these drugs threatens the survival of many living species, including fish and aquatic plants. Chromatographic methods are mainly used for drug determination. However, other highly sensitive and accessible alternative methods have made drug detection possible. These include simple, rapid and highly sensitive fluorimetric methods. Various experimental parameters (solvent type, Δλ selection, influence of CTAC micellar organized media and β-CD cyclodextrins) affecting the performance of the proposed SFS method were optimized. Optimal conditions for both drugs were an aqueous solution of β-CD cyclodextrins (6×10-3 M) with a Δλ = 80 nm. Interesting limits of detection and quantification were found, respectively equal to 0.008 and 0.02 ng/mL for naproxen; 0.31 and 1.039 ng/mL for ibuprofen. This method was applied to tap water collected from Marne la Vallée in France, natural water samples (sea water), STEP effluent samples from Senegal and real pharmaceutical drug samples using the standard addition method. The recovery rates obtained were satisfactory, ranging from 72.79 to 109.80 % for ibuprofen and 85.27 to 109.87 % for naproxen. DSR values are relatively low, ranging from 0.18 to 0.40 % for naproxen and from 1.37 to 2.17 % for ibuprofen. This very interesting result, compared with those obtained in the literature, makes SFS a good alternative for the simultaneous determination of pollutants in the environment, particularly NSAIDs drug residues

Keywords: naproxen, ibuprofen, synchronous fluorescence spectroscopy (SFS), quantification, natural waters

Acknowledgments: Jean-Marie Diéne Bakhoum thanks the Service of Cooperation and Cultural Action (SCAC) of the Embassy of France in Dakar (Senegal) for PhD Grant in support of this work

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